|
KMID : 1039120180070010076
|
|
Clinical and Experimental Vaccine Research
2018 Volume.7 No. 1 p.76 ~ p.81
|
|
|
Status of group B streptococcal vaccine development
|
|
Lin Shun Mei
Zhi Yong
Ahn Ki-Bum
Lim Sang-Yong
Seo Ho-Seong
|
|
|
Abstract
|
|
|
|
Streptococcus agalactiae (group B streptococcus, GBS) is a leading causal organism of neonatal invasive diseases and severe infections in the elderly. Despite significant advances in the diagnosis and treatment of GBS infections and improvement in personal hygiene standards, this pathogen is still a global health concern. Thus, an effective vaccine against GBS would augment existing strategies to substantially decrease GBS infection. In 2014, World Health Organization convened the first meeting for consultation on GBS vaccine development, focusing on the GBS maternal immunization program, which was aimed at reducing infections in neonates and young infants worldwide. Here, we review the history of GBS infections, the current vaccine candidates, and the current status of immunogenicity assays used to evaluate the clinical efficacy of GBS vaccines.
|
|
|
KEYWORD
|
|
|
Vaccines, Group B streptococcus, Streptococcus agalactiae, Conjugate vaccines, Polysaccharides
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|